Status:
UNKNOWN
Liver and Spleen Stiffness Measured by 2D-SWE for Diagnosis of Liver Fibrosis in Patients With cACLD
Lead Sponsor:
Fifth Affiliated Hospital, Sun Yat-Sen University
Conditions:
Liver Fibrosis
Liver Cirrhosis
Eligibility:
All Genders
18+ years
Brief Summary
A observational diagnostic study will be conducted to evaluate the performance of liver stiffness and spleen stiffness measured by 2D-shear wave elastography (2D-SWE) for diagnosing liver fibrosis in ...
Detailed Description
Patients with chronic liver disease who visit Fifth Affiliated Hospital, Sun Yat-Sen University will be enrolled from October 2023 to January 2025. Their liver stiffness measured by transient elastogr...
Eligibility Criteria
Inclusion
- Age≥18 years old;
- Chronic liver disease (alcoholic liver disease, chronic hepatitis B, chronic hepatitis C or non-alcoholic fatty liver disease);
- No previous decompensation-related manifestations (such as ascites, gastrointestinal varicose bleeding, hepatic encephalopathy, etc.);
- Informed consent has been signed.
Exclusion
- Hepatocellular carcinoma or other advanced malignant tumor;
- Acute liver disease or ALT≥5×ULN;
- Persistent substance abuse other than alcohol;
- Pregnancy or HIV infection;
- There are contraindications of percutaneous liver biopsy (such as serious abnormality of coagulation function, etc.);
- There are conditions that seriously affect TE and 2D-SWE measurements (such as the intercostal space is too narrow, BMI≥30, etc.);
- Subjects considered unsuitable for including in this study but not included by the above exclusion criteria.
Key Trial Info
Start Date :
November 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 1 2025
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT06147934
Start Date
November 1 2023
End Date
January 1 2025
Last Update
November 28 2023
Active Locations (1)
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1
The Fifth Affiliated Hospital, Sun Yat-sen University
Zhuhai, Guangdong, China, 519000