Status:
UNKNOWN
Control of Iatrogenic Endobronchial Bleeding by Tranexamic Acid, Adrenalin and Hemagglutinase
Lead Sponsor:
China-Japan Friendship Hospital
Collaborating Sponsors:
The Second Affiliated Hospital of Harbin Medical University
The First Affiliated Hospital of Nanchang University
Conditions:
Iatrogenic Endobronchial Bleeding
Eligibility:
All Genders
18-90 years
Phase:
EARLY_PHASE1
Brief Summary
A prospective national multi-center study will be conducted to evaluate the effectiveness of hemocoagulase in iatrogenic airway bleeding in a large class III hospital, such as the Second Affiliated Ho...
Eligibility Criteria
Inclusion
- During diagnostic bronchoscopy, patients with bronchial bleeding that was not successfully controlled with cold (4°C) saline (3 times within 60 seconds, 5ml each time).
Exclusion
- 1: Patients with contraindications for diagnostic flexible bronchoscopy.
- 2: Coagulopathy (PV INR \>1.3).
- 3: Thrombocytopenia (\<50x10\^9) or anemia (hgb \<80 g/L).
- 4: Direct oral anticoagulant, low molecular weight heparin, or antiplatelet therapy.
- 5: Thrombophilia, history of pulmonary embolism or deep vein thrombosis.
- 6: Contraindications for the use of epinephrine in the bronchus.
- 7: Coronary artery disease, cerebrovascular disease, history of rapid arrhythmias.
- 8: Uncontrolled pulmonary hypertension.
- 9: Cardiovascular decompensation.
- 10: Severe hypoxia (PaO2 \<60mmHg, SaO2 \<90%, FiO2 \>=60%).
Key Trial Info
Start Date :
December 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2024
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT06149091
Start Date
December 1 2023
End Date
December 31 2024
Last Update
November 28 2023
Active Locations (1)
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1
China-Japan Friendship Hospital
Beijing, Beijing Municipality, China, 100029