Status:
COMPLETED
ASCT Versus Chemotherapy as First-Line Consolidation Therapy inT-Cell Lymphoma
Lead Sponsor:
Huazhong University of Science and Technology
Collaborating Sponsors:
Peking University People's Hospital
Ruijin Hospital
Conditions:
T-cell Lymphoma Adults
Eligibility:
All Genders
18-75 years
Brief Summary
To compare the effectiveness of autologous hematopoietic stem cell transplantation and chemotherapy as first-line consolidation therapy after obtaining a complete therapeutic response in T-cell lympho...
Detailed Description
T-cell lymphoma is characterized by high molecular heterogeneity, high disease aggressiveness, and high chemotherapy resistance rate, and the prognosis is extremely poor. Autologous hematopoietic stem...
Eligibility Criteria
Inclusion
- Pathological diagnosis of T-cell lymphoma, including, but not limited to, Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), Angioimmunoblastic T-cell lymphoma (AITL) , ALK-negative anaplastic large cell lymphoma (ALCL, ALK-negative), Enteropathy-associated T-cell lymphoma (EATL), hepatosplenic T-cell lymphoma (HSTCL), and extranodal NK/T-cell lymphoma (ENKTL )
- 18-75 years old;
- Achievement of a complete response (CR) post-chemotherapy;
- Obtaining a complete response (CR) after chemotherapy;-Consistent follow-up visits post-treatment, with comprehensive follow-up data available;
Exclusion
- Initially diagnosed with ALK-positive Anaplastic Large Cell Lymphoma (ALCL, ALK- - -CR was not achieved after treatment;
- Lack of complete follow-up information or lack of consent for follow-up and data collection
- T-cell lymphoma secondary to other malignancies
Key Trial Info
Start Date :
January 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 1 2023
Estimated Enrollment :
347 Patients enrolled
Trial Details
Trial ID
NCT06149390
Start Date
January 1 2014
End Date
July 1 2023
Last Update
November 29 2023
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