Status:
RECRUITING
Changes in Microbial Status From Dentate, Edentulous and After Dental Implant Placement
Lead Sponsor:
Case Western Reserve University
Conditions:
Edentulous Mouth
Periodontal Diseases
Eligibility:
All Genders
21+ years
Brief Summary
The objectives of this study are to analyze the oral microbiome modulations occurring during the transition from partial (with some residual teeth) to full edentulous (without remaining teeth) status ...
Detailed Description
The introduction of dental implants has significantly changed the treatment approach for prosthetic rehabilitation of partially and edentulous patients. In the last decades an increasing number of pat...
Eligibility Criteria
Inclusion
- At least 21 years of age
- Diagnosis of Stage III or IV periodontitis based on full mouth probing and full mouth x-rays
- Planned for full mouth extraction and replacement by dental implants.
- Rehabilitation with Implant supported restorations either maxilla and/ or mandible.
- At least 2 implants available for examination.
- No bone augmentation required.
Exclusion
- Conditions requiring chronic routine prophylactic use of antibiotics.
- Conditions requiring prolonged use of steroids.
- History of leukocyte dysfunction and deficiencies
- Bleeding disorders
- History of neoplastic disease requiring use of radiation or chemotherapy
- Metabolic bone disorders
- Uncontrolled endocrine disorder
- Use of any investigational drug or device within the 30 day period prior to implant surgery.
- 10\. Alcoholism or drug abuse 11. Patient infected with HIV 12. Condition or circumstances, in the opinion of the investigator, which would prevent completion of study participation or interfere with analysis of study results, such as history of non-compliance, unreliability.
- Local Exclusion Criteria
- Local inflammation
- Mucosal disease such as erosive lichen planus
- History of local irradiation therapy
- Osseous lesion.
- Active infection with suppuration or fistula track.
- Persistent intraoral infection different than periodontitis
Key Trial Info
Start Date :
August 16 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 1 2027
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT06149585
Start Date
August 16 2023
End Date
May 1 2027
Last Update
June 4 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Case Western Reserve University Department of Periodontics
Cleveland, Ohio, United States, 44106