Status:
RECRUITING
An Observational Study of Menopausal Symptom in Patients With Gynecological Malignancy After Oophorectomy
Lead Sponsor:
Anhui Provincial Hospital
Conditions:
Gynecological Malignancies
Menopausal Symptoms
Eligibility:
FEMALE
18-55 years
Brief Summary
Through long-term dynamic monitoring of gynecologic malignant tumor patients undergoing early menopause after ovaries resection in our center, we explored the changes in menopausal symptoms and bone h...
Detailed Description
Gynecological malignancies are affecting the health of more and more women in the world, and the age of onset is also gradually younger. For women of reproductive age with gynecologic malignancies, su...
Eligibility Criteria
Inclusion
- Premenopausal women with gynecological malignancies aged 18-55 years old;
- Tumor types include endometrial cancer, cervical cancer, epithelial ovarian cancer;
- All patients received standard stage operation and treatment;
- Patients with bilateral ovaries resection; ⑤Voluntarily participate in this study, willing to sign informed consent, and have long-term follow-up conditions.
Exclusion
- Menopause (women over 40 years of age stop menstruation for 12 months, excluding pregnancy and other diseases that may cause amenorrhea can be clinically diagnosed as menopause); Or AMH \< 0.2ng/ml (China Menopause Management and Menopause Hormone Therapy Guidelines 2023 edition); Or FSH\> 40 mIU/ml after two checks within one month;
- Other tumors were combined within 2 years and were still in radiotherapy, chemotherapy or hormone therapy;
- Diagnosis of immunodeficiency disease or active hepatitis B, C, active tuberculosis; ④Serious organic diseases of the organs, etc., can not cooperate with the study follow-up; ⑤Long-term use of hormonal drugs for rheumatic system diseases, such as glucocorticoids;
- Patients who have previously received pelvic or abdominal radiotherapy; ⑦ ECOG score ≥3 points; ⑧The patient did not sign informed consent or was unwilling to accept follow-up interviews.
Key Trial Info
Start Date :
December 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2033
Estimated Enrollment :
490 Patients enrolled
Trial Details
Trial ID
NCT06151028
Start Date
December 1 2023
End Date
December 31 2033
Last Update
March 7 2024
Active Locations (1)
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1
Anhui Provincal Hospital
Hefei, Anhui, China