Status:
UNKNOWN
Effect of Alpha-Lipoic Acid Supplementation on the Incidence of Postoperative Atrial Fibrillation in Cardiac Surgery Patients
Lead Sponsor:
Ain Shams University
Conditions:
Postoperative Atrial Fibrillation
Eligibility:
All Genders
18-75 years
Phase:
PHASE4
Brief Summary
ALA is administered orally since it is without difficulty absorbed in the stomach. ALA goes through the blood brain barrier and does not show toxic effects and actions at doses used for prophylactic a...
Detailed Description
Investigators computed on the basis of findings from a prior study found the incidence of POAF after cardiac surgery of about 25% . Assuming a slightly lower alpha-lipoic acid' effect to previous stud...
Eligibility Criteria
Inclusion
- I
- Male or female patients above 18 years of age who are scheduled for cardiac surgery.
Exclusion
- Any urgent or emergency surgery.
- Poor Left ejection volume (EF \< 30%).
- Intake of steroids or any antiarrhythmic drugs except beta blockers during the last month before surgery
- Unable or unwilling to provide informed written consent.
- Pregnancy or lactation
- Known hypersensitivity to the study drug.
- Current treatment with antioxidants or alpha-lipoic acid for any indication.
- Infection or inflammatory disease except coronary artery disease.
- Left atrium size \>70 mm.
Key Trial Info
Start Date :
January 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 1 2024
Estimated Enrollment :
350 Patients enrolled
Trial Details
Trial ID
NCT06151652
Start Date
January 1 2023
End Date
April 1 2024
Last Update
February 1 2024
Active Locations (1)
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1
Ain shams university
Cairo, Egypt