Status:
RECRUITING
Ablate and Pace HIS Study
Lead Sponsor:
University Hospitals, Leicester
Collaborating Sponsors:
Medtronic
Conditions:
HIS Bundle Pacing
Atrial Fibrillation
Eligibility:
All Genders
18-100 years
Phase:
NA
Brief Summary
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, and estimates suggest its prevalence is increasing. Despite the advances in AF ablation strategies, the outcome of ablation pr...
Detailed Description
The Ablate and Pace HIS Study is a single-centre, prospective randomised single-blinded study, recruiting a sub-population of patients with AF who are deemed not fit for rhythm control strategy. These...
Eligibility Criteria
Inclusion
- Aged 18 or above
- Symptomatic AF, New York Heart Association (NYHA) class II-IV
- Willing to consent for the study
- AF regardless type, deemed not suitable for rhythm control strategy that has been referred for AVN ablation with one of the following:
- Impaired LV function, EF \<50 %. And or
- Raised N-Terminal Pro B-type Natriuretic Peptide ( NT-ProBNP) \>365 ng/L
Exclusion
- Patient who has already got a pacemaker in situ
- Known severe LVSD when biventricular device is the thought to be the preferred pacing modality
- Females in child bearing period
- Lack of capacity to consent
- Other serious medical condition with life expectancy of less than 1 year
- Less than 18 years
- Unwilling to consent for the study
Key Trial Info
Start Date :
October 24 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 29 2028
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT06152406
Start Date
October 24 2023
End Date
February 29 2028
Last Update
January 5 2026
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University Hospitals of Leicester NHS Trust
Leicester, Leicestershire, United Kingdom, LE1 5WW