Status:
UNKNOWN
Comparision Between Paracetamol and Ibuprofen in Closure of Patent Ductus Arteriosus
Lead Sponsor:
Assiut University
Conditions:
Patent Ductus Arteriosus
Eligibility:
All Genders
28-37 years
Phase:
PHASE2
Brief Summary
To compare efficacy and safety of paracetamol and ibuprofen for the pharmacological closure of patent ductus arteriosus (PDA) in preterm infants.
Detailed Description
The ductus arteriosus (DA) is an essential fetal blood vessel that connects the pulmonary artery to the aorta and serves to shunt blood away from the lungs into the umbilical placental circulation whe...
Eligibility Criteria
Inclusion
- preterm infants
- with gestational age ≤37weeks
- who had echocardiographically confirmed significant PDA.
Exclusion
- Preterm neonates
- with major congenital anomalies,
- life threatening sepsis,
- NEC,
- IVH,
- urine output \<1ml/kg/h in the last 24 h,
- serum creatinine concentration \>1.5 mg/dl, -platelet count \<100,000/ml,
- complex congenital heart,
- or duct-dependent lesions.
Key Trial Info
Start Date :
December 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2026
Estimated Enrollment :
56 Patients enrolled
Trial Details
Trial ID
NCT06152796
Start Date
December 1 2023
End Date
January 1 2026
Last Update
December 1 2023
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