Status:
UNKNOWN
Local Sleep in Idiopathic Hypersomnia
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Idiopathic Hypersomnia
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Idiopathic hypersomnia (IH) is a rare and poorly studied disease characterized by excessive daytime sleepiness different from that of narcolepsy (sleep drunkness non-recuperative naps and nocturnal bl...
Detailed Description
Local sleep is a recent concept, suggesting a local regulation of the sleep-wake state, characterized for example in wakefulness by slow waves restricted to certain regions of a globally awake brain, ...
Eligibility Criteria
Inclusion
- Inclusion Criteria :
- Healthy subjects and people with IH and NT1:
- \>18 years old, of both sexes, without legal protection.
- Affiliated to the French social security system
- Signature of free and informed consent
- Fluency in spoken and written French
- Specific to people with IH:
- Diagnosis of IH according to the ICSD-3, already made in the sleep pathology department of the Pitié after a specialized medical interview and a standardized 48h assessment (Night 1+TILE+Night 2+two naps): Sleep time \> 660 min or TILE latency \<8 min, \<2 SOREMPs.
- Specific to people with NT1:
- Diagnosis of narcolepsy type 1 according to the ICSD-3, already made in the sleep pathology department of the Pitié after a specialized medical interview and a standardized 48h workup (Night 1+TILE+Night 2+two naps) and sometimes a lumbar puncture: hypocretin \<110 pmol/L in CSF or cataplexy and TILE latency \<8 min, \>1 SOREMP.
Exclusion
- Shift or night work
- Sleep debt on the day of the recording (questioning and sleep diary one week before the recording)
- Other sleep pathology causing daytime sleepiness (sleep apnea, insomnia, parasomnia for example)
- Cerebral neurological pathology
- Depressive episode
- Any psychotropic treatment modifying the EEG structure
- Failure to wean from arousing treatment on the day of the test.
- Inability to travel by transport or to be transported by a relative on the day of the recording.
Key Trial Info
Start Date :
December 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2024
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT06153615
Start Date
December 1 2023
End Date
May 1 2024
Last Update
December 1 2023
Active Locations (1)
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1
Pitié Salpêtrière
Paris, France