Status:
UNKNOWN
The Effect of Nitrate Supplement on the Oral Microbiome and Saliva in Dental Erosion
Lead Sponsor:
University of Portsmouth
Conditions:
Dental Erosion
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
Dental erosion happens when teeth lose some of their parts because of acid from the things people eat and/or drink or even from their stomach. It can make their teeth hurt and become sensitive. The mo...
Detailed Description
Upon consent being granted, several samples and measurements will be collected from the participant during this research study spanning over 3 visits. The proposed study is part of a PhD educational ...
Eligibility Criteria
Inclusion
- Eligibility Criteria A) Healthy volunteers Group
- Be aged 18 to 75 years inclusive
- Have a minimum of 20 natural uncrowned teeth (excluding 3rd molars) present
- Give written informed consent
- Be in good general health and oral health (without active caries lesions, gingivitis, periodontitis.
- No diseases of the soft or hard tissues of the oral cavity
- No other oral condition affecting the composition of the oral fluids and presented normal salivary flow (stimulated salivary flow \>1 mL/min, unstimulated salivary flow \> 0.25 mL/min; salivary pH \> 6)
- Show no evidence of dental erosion or/and active dental caries (with BEWE score ≤8 per extant cumulative score per patient and no clinically visible decayed teeth) B) Dental erosion group Inclusion Criteria
- 1\. Same as above of healthy volunteers (1-6). 2. Show evidence of dental erosion (with BEWE score \> 8 per extant cumulative score per patient and one score 3 in a sextant. BEWE is a simple, reproducible and convenient scoring system that can be used with the diagnostic criteria for recording clinical findings and examining dental hard tissues other than for caries, guiding the management of erosive tooth wear.
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Exclusion
- Smokers, using mouthwash or tongue scrapes.
- Consumption of beetroot juice in normal diet (This will be determined from responses on the diet form).
- Diagnosed with alcoholism (or drinking more than four times a week, or consuming at least 40 g in males and 20 g in females per day)
- Presenting conditions associated with vomiting (e.g. anorexia or bulimia), bruxism and Gastro-oesophageal reflux disease (GORD)
- Occupations associated with increased risk of erosion, such as swimmers and battery, charging and galvanizing workers.
- Wearing certain types of dental work on specific teeth (e.g., orthodontic appliances, extensive dental bridges, or recent oral surgery
- Use of antibiotics three (3) months prior to or during this study
- Use of any over the counter medications other than analgesics or have a known medical condition or currently taking any medication
- Pregnant or breastfeeding
- 8\. Participation in another clinical study in the month preceding this study 9. Medical condition which requires pre-medication prior to dental visits/procedures.
- 10\. Participants who have eaten/had anything to drink up to two hours before providing a sample (Two hours prior to the trial, participants will be instructed to eat a self-selected light meal and drink 500 ml of water. No other food or fluid will be allowed
Key Trial Info
Start Date :
November 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 20 2024
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT06156618
Start Date
November 1 2023
End Date
December 20 2024
Last Update
December 5 2023
Active Locations (1)
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1
University of Portsmouth Academy
Portsmouth, United Kingdom, PO1 2QG