Status:
RECRUITING
Prediction of Hepatocellular Carcinoma Recurrence After Curative Treatment by Longitudinal Monitoring MRD Based on ctDNA
Lead Sponsor:
Zhujiang Hospital
Conditions:
Hepatocellular Carcinoma Resectable
Eligibility:
All Genders
18-75 years
Brief Summary
This study will conduct a prospective cohort study to verify the predictive value of ctDNA-MRD longitudinal monitoring model in predicting postoperative recurrence, verify whether ctDNA-MRD longitudin...
Detailed Description
The recurrence rate of hepatocellular carcinoma after curative treatment is high, and the minimal residual disease(MRD) in patients is the major cause of liver cancer recurrence, and the MRD is an imp...
Eligibility Criteria
Inclusion
- Male or female patients aged 18-75 years;
- Preoperative imaging examination diagnosed hepatocellular carcinoma (BCLC) stage 0 / stage A/stage B, eligible for radical surgery;
- ECOG physical status score is 0-1;
- Child-Pugh score is 5-6 points (Level A);
- Not received any anti-tumor therapy;
- Laboratory tests were at normal levels within 7 days before enrollment.
Exclusion
- Patient can't provide blood samples for ctDNA testing;
- Patient with two or more types of tumors at the same time;
- Non-primary liver lesions;
- Pregnant or lactating women;
- Patient with a history of other malignant tumors within the past 5 years or at the same time, except cured skin basal cell carcinoma, cervical carcinoma in situ and thyroid papillary carcinoma;
- Patient with serious heart disease;
- Other conditions deemed unsuitable for inclusion by the researcher.
Key Trial Info
Start Date :
November 20 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 30 2026
Estimated Enrollment :
255 Patients enrolled
Trial Details
Trial ID
NCT06157060
Start Date
November 20 2023
End Date
December 30 2026
Last Update
March 28 2024
Active Locations (7)
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1
The Sixth Affiliated Hospital of South China University of Technology
Foshan, Guangdong, China
2
Zhujiang Hospital of Southern Medical University
Guangzhou, Guangdong, China, 510220
3
Affiliated Cancer Hospital and Institute of Guangzhou Medical University
Guangzhou, Guangdong, China
4
Guangdong Provincial Hospital of Traditional Chinese Medicine
Guangzhou, Guangdong, China