Status:
UNKNOWN
Characterizing Response to Antipsychotics in Schizophrenia
Lead Sponsor:
The Royal Ottawa Mental Health Centre
Collaborating Sponsors:
The Royal's Institute of Mental Health Research
Conditions:
Schizophrenia
Schizoaffective Disorder
Eligibility:
All Genders
18-55 years
Brief Summary
The goal of this research project is to develop MRI-based biomarkers to identify patients with schizophrenia who are most likely to benefit from first-line antipsychotic or clozapine treatment. The MR...
Detailed Description
Currently, we cannot predict who will get better on first-line antipsychotic versus clozapine treatment. Although much evidence shows that dopamine and glutamate function are related to treatment resp...
Eligibility Criteria
Inclusion
- Are voluntary and competent to consent to the study
- Are between the ages of 18-55
- Are English literate
- Have a diagnosis of schizophrenia or schizoaffective disorder
- Are currently taking primarily olanzapine or clozapine
Exclusion
- Medication for the treatment of schizophrenia or schizoaffective disorder has changed in the past month
- Have a significant neurologic, neurodevelopmental, cardiovascular, renal, hepatic, hematological, gastrointestinal, pulmonary, or metabolic-endocrine disorder
- Are pregnant or breastfeeding
- Acquire positive urine test result for all drugs of abuse including cannabis
- Have met DSM-5 criteria for substance use disorder other than tobacco in the last 6 months
- Have a history of significant head trauma with loss of consciousness for more than 5 minutes
- Have any contraindication to MRI
- Have any other condition that in the opinion of the investigator(s) could create a hazard to the subject's safety, endanger the study procedures, or interfere with the interpretation of study results
Key Trial Info
Start Date :
January 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 30 2024
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT06159322
Start Date
January 1 2023
End Date
January 30 2024
Last Update
December 6 2023
Active Locations (1)
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1
The Royal's Institute of Mental Health Research
Ottawa, Ontario, Canada, K1Z 7K4