Status:
NOT_YET_RECRUITING
Ventilation Using Radiographic Examination: Functional Lung Imaging Techniques for the Reduction of Toxicity in Functional Avoidance Radiation Therapy
Lead Sponsor:
University of Sydney
Collaborating Sponsors:
National Health and Medical Research Council, Australia
Northern Sydney and Central Coast Area Health Service
Conditions:
Lung Neoplasm
Eligibility:
All Genders
18+ years
Brief Summary
The goal of this observational validation study is to determine the best implementation of fluoroscopic and CT ventilation imaging in patients having non-stereotactic ablative body radiotherapy (non-S...
Detailed Description
Lung cancer is the leading cause of cancer mortality worldwide with non-small cell lung cancers (NSCLC) accounting for approximately 85% of all lung cancers diagnosed. Surgery, immunotherapy, chemothe...
Eligibility Criteria
Inclusion
- Aged 18 years or older.
- Eastern Cooperative Oncology Group (ECOG) performance status 0-2.
- Histologically proven Stage II-IV non-small cell lung cancer as determined using the IASLC International Association for the Study of Lung Cancer (IASLC) 8th edition lung cancer staging guidelines.
- To be treated with curative intent (stage II-III) or palliative intent (stage IV) with non-SABR external beam radiotherapy (e.g. 60 Gy in 30 treatments for curative intent or 30 Gy in 5 treatments for palliative intent).
- Pulmonary function tests within 8 weeks of registration.
- 4DCT simulation for radiation therapy.
- Willingness to give written informed consent.
- Willingness and ability to comply with the study procedures and visit requirements.
- Available for follow up for 1 year or until death, whichever occurs first.
Exclusion
- Prior radiation therapy to the thorax.
- Prior surgery for this cancer.
- Prior chemotherapy for this cancer.
- Interstitial lung disease.
- Pregnant women.
Key Trial Info
Start Date :
July 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 1 2026
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT06159660
Start Date
July 1 2024
End Date
September 1 2026
Last Update
July 9 2024
Active Locations (1)
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1
Royal North Shore Hospital
St Leonards, New South Wales, Australia, 2065