Status:
COMPLETED
Role of Exercise in Chronic Liver Disease Patients Undergoing Liver Transplantation
Lead Sponsor:
Institute of Liver and Biliary Sciences, India
Conditions:
Chronic Liver Disease and Cirrhosis
Frailty
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The goal of this randomised clinical trial (open label) is to test the effect of supervised aerobic and resistance exercises in chronic liver disease patients being planned for living donor liver tran...
Detailed Description
1. Aim and Objective - Primary objective: To assess effects of pre-operative aerobic and resistance exercises in decompensated CLD patients planned for LDLT on the measures of frailty after 1 month of...
Eligibility Criteria
Inclusion
- Voluntary adult patient (\>18 years), decompensated chronic liver disease patients planned for LDLT, and Who pass the screening tests done in the OPD
- Able to follow the introductory level exercises as per the protocol in the OPD without any adverse event.
- No drop in the spO2 less than 93% on a 6 minute walk test.
Exclusion
- Patients with a physical disability (upper or lower limb deformity/abnormality)
- Exercise intolerance or inability to follow exercise regime.
- Patients who fail the screening tests.
- Patients on the following drugs-
- Higher corticosteroid dose (\>0.1mg/kg/day),
- BCAA (Branched chain amino acids)
- Growth hormone, testosterone, SARMs,
- Ghrelin agonists, myostatin antibodies,
- Activin IIR antagonists, angiotensin converting enzyme inhibitors,
- Espindolol (mixed beta agonist and antagonists), and
- Fast skeletal muscle troponin activators.
Key Trial Info
Start Date :
December 15 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 31 2025
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT06163001
Start Date
December 15 2023
End Date
January 31 2025
Last Update
August 24 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Institute of Liver and Biliary Sciences
New Delhi, National Capital Territory of Delhi, India, 110070