Status:
RECRUITING
Chronic Endometritis and Benefits of Antibiotics in Women With Recurrent Miscarriage
Lead Sponsor:
Chinese University of Hong Kong
Conditions:
Recurrent Miscarriage
Eligibility:
FEMALE
20-45 years
Brief Summary
The aim of the study is to estimate the incidence of CE, evaluate the endometrial microorganism of CE, and investigate the therapeutic benefits of antibiotics for women with unexplained recurrent misc...
Detailed Description
Eligible women, based on the inclusion and exclusion criteria, will be recruited from the miscarriage clinic in the Prince of Wales Hospital. Endometrial sampling (ES) will alternatively be conducted ...
Eligibility Criteria
Inclusion
- Women with a history of 2 or more consecutive miscarriages before 24 weeks of gestation
- Women aged 20-45 years old
Exclusion
- Uncorrected uterine anomalies, such as the septate or bicornuate uterus, fibroids (submucous/intramural)
- Untreated hydrosalpinx
- Antiphospholipid syndrome
- Known clinical autoimmune disease
- Undergoing immunotherapy
- Abnormal thyroid function
- Abnormal karyotyping of couples
- Known immunodeficiency pathologies such as diabetes or HIV
- Currently taking other antibiotics or other trial medications or TCM;
- Currently or previously involved in other clinical trials with medication intake;
- Those with active pelvic inflammatory disease or suspicion of infection etc.
Key Trial Info
Start Date :
April 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 31 2027
Estimated Enrollment :
175 Patients enrolled
Trial Details
Trial ID
NCT06163092
Start Date
April 1 2024
End Date
January 31 2027
Last Update
March 20 2025
Active Locations (1)
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1
The Chinese University of Hong Kong
Hong Kong, Hong Kong