Status:
COMPLETED
Effect of Dexmedetomidine vs Esmolol or Placebo on Cerebral Hemodynamics in Septic Shock
Lead Sponsor:
Xinchen Wang
Collaborating Sponsors:
Tibet Autonomous Region People's Hospital
Conditions:
Septic Shock
Stress Response
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Some researchers proposed that the dysregulated response or organ dysfunction can be lessen...
Detailed Description
It is a single-blinded, single-center, randomized trial. Patients with septic shock established within 24 hours in the ICU of Tibet Autonomous Region People's Hospital will be screened for recruitment...
Eligibility Criteria
Inclusion
- 18 \~ 80 years old.
- Patients established septic shock according to sepsis 3.0 criteria.
- Under deep sedation of BIS 40-60 with midazolam and fentanyl.
- After achieving the goal sedation, patients are still with tachycardia (heart rate over 100 b.p.m..
Exclusion
- Pregnancy.
- Patients with severe arrhythmia.
- Patients with aortic or aortic valve disease.
- Patients with mechanical circulatory assist device (e.g. extracorporeal membrane oxygenation (ECMO), intra-aortic balloon pump (IABP), etc).
- Patients with cerebral trauma.
- Any contraindication to the use of transcranial doppler.
Key Trial Info
Start Date :
November 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2023
Estimated Enrollment :
14 Patients enrolled
Trial Details
Trial ID
NCT06169475
Start Date
November 1 2020
End Date
November 1 2023
Last Update
December 13 2023
Active Locations (1)
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1
Peking Union Medical College Hospital, Chinese Academy of Medical Science
Beijing, China