Status:
RECRUITING
A Randomized Controlled Trial of Vitamin D Supplementation on Salivary Biomarkers and Cariogenic Oral Microbiome
Lead Sponsor:
Dow University of Health Sciences
Collaborating Sponsors:
University of Karachi
Conditions:
Dental Caries
White Spot Lesion
Eligibility:
All Genders
12-50 years
Phase:
PHASE4
Brief Summary
The goal of this clinical trial is to compare the treatment effect of vitamin D supplementation and topical fluorides in the population having vitamin D deficiency and Initial Carious Lesions (ICL) on...
Detailed Description
The study investigator will conduct a multi-centered randomized clinical trial in the outpatient department of Operative Dentistry, in three units of Dow University of Health Sciences (DUHS), with par...
Eligibility Criteria
Inclusion
- Patients of all genders and ages ranging from 12-50 years, having at least two teeth with clinically diagnosed Initial Carious Lesions at Moderate Risk of Dental Caries, after written informed consent.
- Patients having vitamin D deficiency.
Exclusion
- Patients who have heavy calculus, gingivitis, or periodontitis.
- Patients using desensitizing toothpaste or mouthwash up to six weeks before the study.
- Patients who have severe intestine or kidney disease, malabsorption syndrome, or any other conditions affecting vitamin D metabolism.
- Patients on antibiotics or probiotics therapy for the last month
- Pregnant females.
- Patients with poor oral hygiene and with excessive dietary exposure to acids and carbohydrates.
Key Trial Info
Start Date :
December 12 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2025
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT06172764
Start Date
December 12 2023
End Date
December 1 2025
Last Update
March 11 2025
Active Locations (1)
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1
Dr Saba Arshad
Karachi, Sindh, Pakistan, 75330