Status:
ACTIVE_NOT_RECRUITING
Effects of Multicomponent Exercise on Subchondral Bone and Cartilage in Postmenopausal Women with Knee Osteoarthritis
Lead Sponsor:
University of Jyvaskyla
Collaborating Sponsors:
University of Oulu
Wellbeing Services County of Central Finland
Conditions:
Osteoarthritis, Knee
Eligibility:
FEMALE
55-75 years
Phase:
NA
Brief Summary
Today, osteoarthritis (OA) is considered a whole-organ disease that is amenable to prevention and treatment in the early stages. Information on the articular cartilage and subchondral bone responses t...
Detailed Description
The study is an 8-month, randomized controlled intervention study with 12-month follow-up in volunteer postmenopausal (55-75-year-old) women with mild radiographic knee OA according to the Kellgren-La...
Eligibility Criteria
Inclusion
- voluntary women 55-75 years of age.
- no history of any illness for which exercise is contraindicated or that would limit participation in the exercise program.
- knee pain during the last 12 months.
- willingness and voluntarily signed informed consent to undergo testing and intervention procedures with all of its aspects.
- weight-bearing knee x-rays show radiographic Kellgren-Lawrence grade 1-2 OA in one or both tibiofemoral joints.
Exclusion
- body-mass index over 35 kg/m2.
- knee instability or trauma that would jeopardize the training.
- inflammatory joint disease.
- intra-articular steroid injections in the preceding 12 months in the knee.
Key Trial Info
Start Date :
June 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2026
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT06173193
Start Date
June 1 2023
End Date
March 1 2026
Last Update
March 30 2025
Active Locations (1)
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1
University of Jyväskylä
Jyväskylä, Finland, 40014