Status:
RECRUITING
Remote Ischemic Conditioning for Cerebral Ischemia in Patients With Takayasu Arteritis (TARIC-1)
Lead Sponsor:
Xuanwu Hospital, Beijing
Conditions:
Cerebral Ischemia
Takayasu Arteritis
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The aim of this study is to evaluate the safety and efficacy of remote ischemic conditioning ( RIC ) in the protection of cerebral ischemia in patients with Takayasu arteritis ( TAK ). The study was d...
Detailed Description
Clinical symptoms, routine follow-up laboratory tests, other serological indicators (VEGF, NGF, ET-1, ACE), PAF, PDGF, etc.), vascular involvement, cranial MRI, vascular injury score, disease activity...
Eligibility Criteria
Inclusion
- All patients fulfilled the 1990 American College of Rheumatology Classification Criteria for TAK
- Inactive state
- Male and female, aged 18-65 years old
- The presence of supra-aortic vascular involvement ( including but not limited to the left and right sides of the common carotid artery, subclavian artery, vertebral artery involvement )
- Decreased cerebral blood perfusion in the whole brain ( compared with healthy people ) or local ( left and right brain contrast ) suggested by pseudo-Continuous arterial spin labeling ( pCASL ) -MRI
- Voluntary participation in this study, signed informed consent
Exclusion
- Complications that endanger the function of important organs, such as uncontrollable heart failure, severe heart valve disease, severe hypertension, severe myocardial ischemia, pulmonary hypertension, acute cerebral infarction, arterial dissection or aneurysm rupture, etc
- There are serious complications, such as poorly controlled diabetes, renal insufficiency, cardiopulmonary insufficiency, mental illness or malignant tumor
- There were moderate to severe stenosis of brachial artery in both upper limbs
Key Trial Info
Start Date :
January 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 31 2025
Estimated Enrollment :
44 Patients enrolled
Trial Details
Trial ID
NCT06178419
Start Date
January 1 2024
End Date
July 31 2025
Last Update
September 19 2024
Active Locations (1)
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1
Department of Rheumatology and Allergy, Xuanwu Hospital, Capital Medical University, Beijing, China
Beijing, Beijing Municipality, China, 100053