Status:
UNKNOWN
Chronic Remote Ischemic Conditioning in Vascular Cognitive Impairment: A Dose Escalation Study
Lead Sponsor:
Augusta University
Collaborating Sponsors:
Georgia Rehabilitation Institute
Conditions:
Age-related Cerebral White Matter Changes
Cognition Disorder
Eligibility:
All Genders
56+ years
Phase:
NA
Brief Summary
To evaluate the dose-response of relevant blood biomarkers to remote ischemic conditioning in patients with age-related cerebral white matter hyperintensities on MRI, in preparation for a subsequent l...
Detailed Description
Objective: The objective of this early phase study is to evaluate the dose-response of relevant blood biomarkers to remote ischemic conditioning in preparation for a subsequent larger efficacy trial. ...
Eligibility Criteria
Inclusion
- Age ≥55 years
- Head MRI in the past 6 months showing no more than moderate age related cerebral white matter changes (Fazekas score 0-2).
- Able to walk without assistance \& independently perform basic activities of daily living.
- Able to understand this study and agree for a valid consent.
Exclusion
- Prior non-lacunar (cortical) stroke. 2. Unable to cooperate with the use of the conditioning device. 3. Confounding illness that might interfere with the interpretation of results (such as active malignancy or multiple sclerosis).
- 4\. Contraindication to transient arm ischemia in either arm (such as symptomatic peripheral artery disease).
Key Trial Info
Start Date :
August 15 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 15 2023
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT06179797
Start Date
August 15 2020
End Date
December 15 2023
Last Update
December 22 2023
Active Locations (1)
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1
Wellstar MCG Health
Augusta, Georgia, United States, 30912