Status:
RECRUITING
Acute Analgesic Effects of DMT on Experimentally Induced Pain in Healthy Participants
Lead Sponsor:
University Hospital, Basel, Switzerland
Conditions:
Healthy
Eligibility:
All Genders
25-75 years
Phase:
PHASE1
Brief Summary
N,N-dimethyltryptamine (DMT) is a classical psychedelic with similar effects like LSD or psilocybin. Preliminary evidence from case series and small open-label trials suggests that psychedelics may be...
Detailed Description
Preliminary evidence from case series and small open-label trials suggests that psychedelics may be promising candidates for the treatment of several pain-related diseases such as chronic pain, migrai...
Eligibility Criteria
Inclusion
- Age between 25 and 75 years old
- Sufficient understanding of the German language
- Understanding of procedures and risks associated with the study
- Willing to adhere to the protocol and signing of the consent form
- Willing to refrain from the consumption of illicit psychoactive substances during the study 6. Willing not to operate heavy machinery for 24 hours after the study session.
- 7\. Willing to use effective birth control throughout study participation 8. Body mass index between 18-29 kg/m2 and body weight within 50 - 90kg
Exclusion
- Chronic or acute medical condition
- Current or previous major psychiatric disorder
- Psychotic disorder or bipolar disorder in first-degree relatives
- Hypertension (SBP\>140/90 mmHg) or hypotension (SBP\<85 mmHg)
- Hallucinogenic and/or dissociative substance use (not including cannabis) more than 15 times or any time within the previous two months
- Pregnancy or current breastfeeding
- Participation in another clinical trial (currently or within the last 30 days)
- Use of medication that may interfere with the effects of the study medication
- Tobacco smoking (\>10 cigarettes/day)
- Consumption of alcoholic beverages (\>20 drinks/week)
Key Trial Info
Start Date :
January 23 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 28 2025
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT06180759
Start Date
January 23 2025
End Date
September 28 2025
Last Update
February 3 2025
Active Locations (1)
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1
Clinical Pharmacology & Toxicology, University Hospital Basel
Basel, Switzerland, 4056