Status:
UNKNOWN
Leucoaraiosis and Multimodal MRI With Fingerprinting Technique
Lead Sponsor:
Lille Catholic University
Collaborating Sponsors:
University Hospital, Lille
Conditions:
Leukoaraiosis
Magnetic Resonance Imaging
Eligibility:
All Genders
18+ years
Brief Summary
Leukoaraiosis (LA) corresponds to an alteration of the encephalic white matter, linked to chronic hypoxia. Its pathophysiology, which has been partially elucidated, is underpinned by chronic changes i...
Eligibility Criteria
Inclusion
- Patient over 40 years of age
- Suffering from leucoaraiosis
- Diagnosed via cerebral MRI or CT scan performed by the St Philibert Hospital imaging department
- For the groups:
- incidental LA (patients included in group 1): on the MRI, FLAIR images showed the presence of hyperintense white matter lesions, assessed at a minimum FAZEKAS grade 2+2, the origin of which was related to small artery disease discovered incidentally or during acute management in GHICL's neurovascular intensive care unit. The CT scan revealed hypodense patches of deep periventricular white matter, also of minimal Fazekas grade 2+2.
- LA and ischemia (patients included in group 2): on the MRI, FLAIR images show the presence of hyperintense white matter lesions with an extent assessed at a minimum grade of FAZEKAS 2+2: their origin is related to small artery disease discovered during acute management of cerebral ischemia in the GHICL's Neurovascular Intensive Care Unit.
- LA and cerebral hemorrhage (patients included in group 3): on the MRI, FLAIR images show the presence of hyperintense white matter lesions of minimal FAZEKAS grade 2+2: their origin is related to small artery disease discovered during the acute management of a cerebral hemorrhage, in the GHICL's Neurovascular Intensive Care Unit.
Exclusion
- Claustrophobia preventing MRI scan
- MRI contraindication
- White matter lesions with diagnosis not formally established, doubtful, multifactorial or related to a differential diagnosis
- Patients with dementia or pathology that precludes longitudinal follow-up
- Institutionalized patients
- Agitation not allowing MRI to be performed
- Pregnant women
- Patients under guardianship
- Patients objecting the use of their data
Key Trial Info
Start Date :
November 14 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 30 2025
Estimated Enrollment :
250 Patients enrolled
Trial Details
Trial ID
NCT06181981
Start Date
November 14 2022
End Date
November 30 2025
Last Update
December 26 2023
Active Locations (1)
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1
Grupement des Hôpitaux de l'Institut Catholique de Lille
Lomme, France, 59462