Status:
RECRUITING
The Prognostic Value of the Degree of Pathological Response of Induction Chemotherapy for NPC
Lead Sponsor:
Jiangxi Provincial Cancer Hospital
Conditions:
Nasopharyngeal Carcinoma
Pathologic Complete Response
Eligibility:
All Genders
18+ years
Brief Summary
This study aims to explore the prognostic value of pathological remission after one cycle of induction chemotherapy in locally advanced nasopharyngeal carcinoma, and the change of immune micro-environ...
Eligibility Criteria
Inclusion
- Ability to sign informed consent
- Age \> 18 years at time of study entry
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 (amend based on specific study)
- Histological confirmation of NPC (regardless if EBER positive or negative)
- Locally advanced NPC, UICC stage III-IVa
- Subject is willing and able to comply with the protocol for the duration of the study including undergoing treatment and scheduled visits and examinations including follow up.
Exclusion
- Concurrent enrolment in another clinical study, unless it is an observational (non-interventional) clinical study or during the follow-up period of an interventional study
- Distant metastases
- Prior systemic anti-cancer therapy (chemotherapy, immunotherapy, endocrine therapy, targeted therapy, radiotherapy, biologic therapy, tumour embolization, monoclonal antibodies) of the locally advanced NPC.
- History of another primary malignancy
- Female patients who are pregnant
- Known allergy or hypersensitivity to any drugs
- Judgment by the investigator that the patient is unsuitable to participate in the study and the patient is unlikely to comply with study procedures, restrictions and requirements.
Key Trial Info
Start Date :
January 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 30 2029
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT06182657
Start Date
January 1 2024
End Date
June 30 2029
Last Update
February 8 2024
Active Locations (1)
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1
Jingao Li
Nanchang, Jiangxi, China, 330029