Status:
NOT_YET_RECRUITING
NIV Versus HFO for Acute Exacerbations of Interstitial Lung Diseases
Lead Sponsor:
ADIR Association
Conditions:
Interstitial Lung Disease
Acute Respiratory Failure
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The objectives of this study are to compare the physiological consequences of high-flow oxygen therapy and noninvasive mechanical ventilation on ventilation, respiratory work and hemodynamics during a...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Age \> 18 yrs
- Hospitalization in intensive care unit
- Acute exacerbation of a previously/presently documented diffuse (fibrotic) interstitial lung disease
- Dyspnea majoration since at least 1 month
- Alveolar or ground-glass opacities on CT-scan that are superposed to interstitial lung disease and not explained by left heart failure or volume overload
- Hypoxemia requiring oxygen flows \> 6 L/min
- Exclusion criteria:
- Contraindication to noninvasive ventilation or high-flow oxygen therapy
- Immediate indication to endotracheal intubation or hemodynamic assistance
- Body mass index \> 40
- Presence of a pacemaker or an implantable defibrillator
- Presence of cutaneous lesions where Pulmovista® belt should be placed
- Moribund patient
- Pregnant or breastfeeding women or women of childbearing age without an effective method of contraception
- Protected adult patient (tutorship or curatorship)
- Patient deprived of liberty by court or administrative decision
- No possibility to install nasogastric tube
- Endotracheal or tracheostomy tube requirement during the study
- Hemodynamic assistance requirement during the study
Exclusion
Key Trial Info
Start Date :
January 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT06182956
Start Date
January 1 2024
End Date
December 31 2026
Last Update
December 27 2023
Active Locations (1)
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1
ADIR Association
Rouen, France, 76000