Status:
RECRUITING
Superiority of On-demand PrEP Versus PEP on Using Doxycycline for Preventing STI in MSM
Lead Sponsor:
Chinese University of Hong Kong
Conditions:
Sexually Transmitted Diseases, Bacterial
Syphilis
Eligibility:
MALE
18+ years
Phase:
PHASE4
Brief Summary
The goal of this clinical trial is to compare the effectiveness of doxycycline taken for on-demand pre-exposure prophylaxis (DoxyODPrEP) and its post-exposure use (DoxyPEP) in preventing bacterial sex...
Detailed Description
Participants would be randomly assigned to either DoxyODPrEP or DoxyPEP arm, and be instructed to take doxycycline with the respective dosing schedule. They would be followed up for 24 months for nucl...
Eligibility Criteria
Inclusion
- has had sex with another male in the past six months
- normally reside in Hong Kong
- can communicate in written and spoken Chinese or English
- willing and able to give written informed consent
- being willing and able to attend scheduled study clinic visits
- at risk of STI (had condomless sex with more than one man in the past 12 months, history of STI diagnosis in the past 12 months, inclination to have condomless sex, and other HIV-PrEP-eligible criteria)
Exclusion
- Being allergic to tetracycline class medicines
- Currently taking medications that are contraindicated with doxycycline
- Using antibiotics for more than 14 days in the month preceding enrolment
Key Trial Info
Start Date :
March 29 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2028
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT06188442
Start Date
March 29 2025
End Date
December 1 2028
Last Update
April 4 2025
Active Locations (1)
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1
Stanley Ho Centre for Emerging Infectious Diseases
Shatin, Hong Kong