Status:
ACTIVE_NOT_RECRUITING
Brain Stimulation Enhance Post-stroke Walking Survivors and Healthy Adults
Lead Sponsor:
The University of Texas Medical Branch, Galveston
Collaborating Sponsors:
The Claude D. Pepper Older Americans Independence Centers
Conditions:
Cerebral Vascular Accident
Eligibility:
All Genders
21-90 years
Phase:
NA
Brief Summary
Recent studies showed that a non-invasive, low-intensity brain stimulation called transcranial direct current stimulation (tDCS) can effectively increase motor neuron excitability in the brain and the...
Detailed Description
The specific aims and hypotheses are: Aim 1: To explore the trends of locomotor skill acquisition in stroke survivors after anodal tDCS (a-tDCS, real brain stimulation), stroke survivors after sham t...
Eligibility Criteria
Inclusion
- Age between 21 and 90 years
- Medical history of a unilateral stroke occurring ≥ 6 months prior to enrollment
- MRI or CT evidence from the imaging report shown that the stroke involves the corticospinal tract
- Hemiparesis involving the lower extremity (Fugl-Meyer Lower Extremity Motor Test)
- No passive range of motion limitation in bilateral hips and knees
- Limitation of ankle passive range of motion to 10 degrees of dorsiflexion or less
- Visual acuity can be corrected by glasses or contact lens to 20/20
- Able to walk independently with/without assistant devices for 10 meters
- Able to maintain standing position without any assistance \>= 30 sec (Short Physical Performance Battery)
- Evaluation of cognitive status: Mini-mental status examination (MMSE) score ≥ 24
Exclusion
- Pregnant women
- MRI or CT evidence of involvement of the basal ganglia or cerebellum, evidence of multiple lesions, or evidence of any other brain damage or tumors
- Have any metal implants, cardiac pacemakers, or history of seizures
- Ongoing orthopedic or other neuromuscular disorders that will restrict exercise training
- Any vestibular dysfunction or unstable angina
- Significant cognitive deficits (inability to follow a 2-step command) or severe receptive or global aphasia
Key Trial Info
Start Date :
May 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 31 2026
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT06191549
Start Date
May 1 2025
End Date
August 31 2026
Last Update
October 31 2025
Active Locations (1)
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1
University of Texas Medical Branch
Galveston, Texas, United States, 77555