Status:
RECRUITING
Steps Towards Osteoarthritis Prevention
Lead Sponsor:
University of Georgia
Collaborating Sponsors:
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Conditions:
Anterior Cruciate Ligament Injuries
Eligibility:
All Genders
16-40 years
Phase:
NA
Brief Summary
Optimal knee joint loading, which refers to the forces acting on the knee caused by daily activities such as daily steps, plays an essential role in maintaining knee articular cartilage health and red...
Detailed Description
Osteoarthritis (OA) is a leading cause of disability. Identifying modifiable mechanisms of poor knee joint health development for disease prevention strategies are critical to improving long-term heal...
Eligibility Criteria
Inclusion
- Provision of signed and dated informed consent form
- For children, signed and dated informed assent by child and parental permission form by parent/guardian to participate in the study
- Underwent an anterior cruciate ligament reconstruction (ACLR) between 6-60 months prior to enrollment
- Stated willingness to comply with all study procedures and lifestyle considerations and availability for the duration of the study
- Completed all other formal physical therapy and therapeutic exercise regimens, and will not be engaging in any other formal therapy for their ACLR during the study
- Physician clearance for unrestricted activity
- Owning a smartphone
- Demonstrate \< 7,000 steps per day during the screening phase of aim 2 as assessed using the Actigraph Link monitor
Exclusion
- Underwent an ACLR revision surgery due to a previous anterior cruciate ligament (ACL) graft injury
- A multiple ligament surgery was indicated with their ACL injury
- A lower extremity fracture was suffered during the ACL injury
- The participant has previously been diagnosed with any diseases that affect joints is present in either knee including knee osteoarthritis inflammatory arthritis
- Pregnant or plans to become pregnant over next 4 months
- Body mass index (BMI) ≥ 36 kg/m2
- Unable to speak English
- Cochlear implant
- Metal in body (metal fragments, shrapnel, permanent make-up, body piercings that cannot be removed)
- Claustrophobia
- History of seizures
- Pacemaker
Key Trial Info
Start Date :
September 23 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 30 2028
Estimated Enrollment :
56 Patients enrolled
Trial Details
Trial ID
NCT06193343
Start Date
September 23 2024
End Date
January 30 2028
Last Update
June 5 2025
Active Locations (1)
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1
University of Georgia
Athens, Georgia, United States, 30602