Status:
RECRUITING
Study on Biomarkers of Postoperative Delirium in Elderly Cardiac Surgery Patients
Lead Sponsor:
Jining First People's Hospital
Conditions:
Delirium
Eligibility:
All Genders
55-80 years
Brief Summary
To evaluate the relationship between abnormal protein or metabolite expression levels in peripheral blood and postoperative delirium in elderly patients undergoing cardiac surgery.
Eligibility Criteria
Inclusion
- patients between 55 and 80 years old,
- American Society of Anesthesiologists (ASA) physical status of II-III and New York Heart Association grade of II-III.
- The planned cardiac surgery.
- Hospitalization duration not less than 5 days.
- The anesthesia time will be no less than 2 hours.All patients had a normal ability to hear, read and cooperate with neuropsychological tests.
Exclusion
- The pre-operative Montreal Cognitive Assessment (MoCA) score was less than 25,
- Patients with dementia, history of neurological or psychiatric disease, hospital with anxiety depression scale (HADS) over eight points,
- Currently use sedatives or antidepressants, Patients with substance dependence on drugs or alcohol.
- Patients with liver and kidney dysfunction, patients with a history of cardiac surgery.
- Admitted to the ICU for more than two days within the month preceding the current surgery,
- Unable to cooperate with researcher's investigations.
Key Trial Info
Start Date :
September 5 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
February 1 2024
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT06194474
Start Date
September 5 2022
End Date
February 1 2024
Last Update
January 8 2024
Active Locations (1)
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1
Fuhui Yan
Jining, Shandong, China, 272000