Status:

RECRUITING

Mechanisms of Somatic Mutation and Tumor Initiation in Pre-malignant Kidney Tubule Cells

Lead Sponsor:

IRCCS San Raffaele

Collaborating Sponsors:

Università Vita-Salute San Raffaele

Conditions:

Carcinoma, Renal Cell

Von Hippel-Lindau Disease

Eligibility:

All Genders

18+ years

Brief Summary

The goal of this observational study is to analyze somatic mutations in the genome of normal kidney cells from patients affected by kidney cancer predisposition syndrome Von Hippel Lindau (VHL) and co...

Eligibility Criteria

Inclusion

  • Genetic diagnosis of VHL-disease; age (data need to be collected from a population distributed between 25 and 65 years); gender (males and females should be equally represented);

Exclusion

  • patients with bilateral nephrectomy, in dialysis or kidney transplant; use of nephrotoxic drugs

Key Trial Info

Start Date :

June 30 2023

Trial Type :

OBSERVATIONAL

Allocation :

ESTIMATED

End Date :

December 31 2027

Estimated Enrollment :

50 Patients enrolled

Trial Details

Trial ID

NCT06194669

Start Date

June 30 2023

End Date

December 31 2027

Last Update

January 10 2024

Active Locations (1)

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1

IRCCS Ospedale San Raffaele

Milan, Italy, 20132