Status:
RECRUITING
Myocardial Stiffness Evaluation in Patients With Heart Failure With Preserved Ejection Fraction
Lead Sponsor:
Haiyan Wang
Conditions:
Heart Failure With Preserved Ejection Fraction
Eligibility:
All Genders
18-80 years
Brief Summary
The goal of this observational study is to evaluating myocardial stiffness in patients with heart failure with preserved ejection fraction (HFpEF) by intrinsic wave velocity propagation (IVP). The mai...
Detailed Description
The included patients who diagnosed with HFpEF and healthy volunteers at the First Affiliated Hospital of Shandong First Medical University from December 20, 2023 to December 20, 2026. Routine clinica...
Eligibility Criteria
Inclusion
- Meet the diagnostic criteria for HFpEF in the 2022 AHA/ACC/HFSA Guidelines for Heart Failure Management:
- Present with signs and symptoms of heart failure;
- LVEF≥50%;
- There is at least one additional criterion: Increased BNP (BNP≥35pg/ml, NT-pro BNP\>125pg/ml) and resting echocardiography measured E/e' ≥ 15; Stress echocardiography determined E/e' ≥ 15; Cardiac catheterization at rest, PCWP ≥ 15 mmHg or LVEDP ≥ 16 mmHg; The PCWP at peak exercise was ≥ 25 mmHg.
Exclusion
- Acute coronary syndrome, acute heart failure or coronary revascularization in three months;
- HFimpEF, cardiomyopathy, severe valvular heart disease, arrhythmia;
- Thyroid dysfunction, pulmonary hypertension, past or current pulmonary embolism, severe chronic obstructive pulmonary disease, malignancy/renal failure (less than 30) ml/min);
- Poor echocardiogram image quality.
Key Trial Info
Start Date :
December 20 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 20 2027
Estimated Enrollment :
438 Patients enrolled
Trial Details
Trial ID
NCT06196086
Start Date
December 20 2023
End Date
December 20 2027
Last Update
January 9 2024
Active Locations (1)
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1
The First Affiliated Hospital of Shandong First Medical University
Jinan, Shandong, China, 250000