Status:
NOT_YET_RECRUITING
Prevention of Cisplatin-induced Nephrotoxicity
Lead Sponsor:
Mahidol University
Conditions:
Acute Kidney Injury
Renal Tubulopathy
Eligibility:
All Genders
Up to 18 years
Phase:
PHASE2
PHASE3
Brief Summary
The research design is a prospective, randomized, controlled clinical trial in children to study effect of aminophylline in preserving renal function in oncologic patient received cisplatin either com...
Eligibility Criteria
Inclusion
- Age under 18 years old
- Oncology patients who receive cisplatin-based therapy
Exclusion
- Preexisting renal anomalies
- Preexisting GFR less than 60 ml/min/1.73 m2
- Contraindication of aminophylline including structural heart disease, arrhythmia, hyperthyroidism, chronic liver disease, epilepsy
- Aminophylline use within 24 hours prior to study entry
Key Trial Info
Start Date :
December 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 30 2026
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT06196853
Start Date
December 1 2025
End Date
September 30 2026
Last Update
October 7 2025
Active Locations (1)
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1
Siriraj hospital, Mahidol university
Bangkok, Thailand, 10700