Status:
COMPLETED
Is Nociceptive Processing Evoked by Heat Homeostatically Regulated: A Contact-heat Evoked Potentials Study
Lead Sponsor:
Aalborg University
Conditions:
Healthy
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
Homeostatic plasticity is a mechanism that stabilizes neuronal activity to prevent excessive nervous system excitability. This mechanism can be investigated in humans by applying two blocks of non-inv...
Detailed Description
Randomized, cross-over study of four sessions
Eligibility Criteria
Inclusion
- Healthy right-handed men and women aged 18-60 years
- Speak, read, and understand English or Danish
Exclusion
- Pregnant, breastfeeding, or women in childbearing age not using contraceptive methods
- Regular use of cannabis, opioids or other drugs (except contraceptives)
- Current or previous neurologic, musculoskeletal, mental, or other illnesses (e.g. brain or spinal cord injuries, degenerative neurological disorders, epilepsy, major depression, cardiovascular disease, chronic lung disease, etc.)
- Current or previous chronic or recurrent pain condition (other than low back pain in patients recruited for sub-project 6, and this item does not apply to sub-project 8)
- Current regular use of analgesic medication or other medication which may affect the trial (including paracetamol and NSAIDs) For subproject 8, chronic low back pain patients may take analgesic medication provided the dosage is stable
- Open wounds, eczema, scars, or tattoos in the area of the heat stimulation (sub-project 1)
- Lack of ability to cooperate
- Recent history of acute pain particularly in the lower limbs (unless related to low back pain in patients included in sub-project 6 or 8)
- Abnormally disrupted sleep in 24 hours preceding experiment
- Any medical or other condition (i.e. musculoskeletal, cardiorespiratory, neurological, etc.)
- Contraindications to TMS application (history of epilepsy, metal implants in head or jaw, etc.)
- Unable to answer to the "Transcranial Magnetic Stimulation Adult Safety Screen" or tDCS screening questionnaire (see Bilag\_v1\_06092021)
Key Trial Info
Start Date :
November 21 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 4 2024
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT06197529
Start Date
November 21 2023
End Date
March 4 2024
Last Update
May 16 2024
Active Locations (1)
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1
Aalborg University / Center for Neuroplasticity and Pain
Gistrup, Denmark, 9260