Status:
UNKNOWN
Impact of End-tidal Oxygen Monitoring During Preoxygenation Before Intubation for Acute Hypoxemic Respiratory Failure in ICU Setting
Lead Sponsor:
University Hospital, Grenoble
Collaborating Sponsors:
Philips Healthcare
Conditions:
Acute Hypoxemic Respiratory Failure
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The main objective of this pilot study is to determine if our protocole using EtO2 monitoring during preoxygenation before intubation is feasible in a population of critically ill patients in acute hy...
Detailed Description
Background : acute hypoxemic respiratory failure (AHRF) is one of the most common causes of intensive care unit (ICU) admission requiring subsequent tracheal intubation for invasive mechanical ventila...
Eligibility Criteria
Inclusion
- Admitted in ICU
- In AHRF, defined as : respiratory rate greater than 25 breaths per minute or signs of respiratory distress, and a partial pressure of oxygen (PaO2) to FiO2 ratio equal to or below 200 mmHg (calculation of estimated FiO2 under standard oxygen as follows: FiO2 = 0.21 + oxygen flow rate × 0.03).
- Indication to intubate based on physician judgment
- Written consent obtained from the patient, relative, or emergency consent.
Exclusion
- Contraindications to NIV (recent laryngeal, oesophageal, or gastric surgery, and substantial facial fractures)
- Severe haemodynamic failure (Norepinephrine ≥ 0.3 μg/kg/min to maintain MAP ≥ 65 mmHg) or cardiac arrest
- Do not intubate order
- Pregnancy
- breastfeeding
- Refusal to participate
Key Trial Info
Start Date :
January 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2025
Estimated Enrollment :
72 Patients enrolled
Trial Details
Trial ID
NCT06198504
Start Date
January 1 2024
End Date
May 1 2025
Last Update
January 10 2024
Active Locations (2)
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1
University Hospital Grenoble
Grenoble, France, 38043
2
University Hospital Lyon
Lyon, France, 69002