Status:
UNKNOWN
Effect of Esketamine on Depressive Symptoms of Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy
Lead Sponsor:
The Second Hospital of Anhui Medical University
Conditions:
Depressive Symptoms
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
Esketamine, as a powerful analgesic intravenous anesthetic, has a rapid onset and elimination effect, does not inhibit spontaneous respiration, and can slightly stimulate the circulatory system. It ha...
Detailed Description
The bidirectional relationship between obesity and mood disorders is suggested supported by empirical evidence. Obesity increases the risk of depression, and depression predicts the developing of obes...
Eligibility Criteria
Inclusion
- BMI≥40kg/m2 or BMI\>35 kg/m2 with an existing comorbidity
- scheduled for selective LSG
- American Society of Anesthesiologists physical status I-III
- HAMD\>7
- with informed consent
Exclusion
- Patients diagnosed with significant comorbidities, such as cardiopathy, chronic respiratory conditions, abnormal hepatic and/or renal function, coagulation dysfunction, major psychiatric or neurological disorders
- Patients allergy to esketamine or other drugs used in the study
- Patients are scheduled for/plan to have an additional surgery during the 3-month follow-up period
- Patients suffer from acute or chronic pain with analgesics, or take anticathartic, glucocorticoid medications
- Patients involved in another research study
- Patients will likely have problems, in the judgement of the investigator, with maintaining follow-up
- Any other reasons the investigator feels is relevant for excluding the patient
- lack of patient consent
Key Trial Info
Start Date :
January 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2025
Estimated Enrollment :
400 Patients enrolled
Trial Details
Trial ID
NCT06199011
Start Date
January 1 2024
End Date
December 1 2025
Last Update
January 10 2024
Active Locations (0)
Enter a location and click search to find clinical trials sorted by distance.
No Results Found
We couldn’t find results for the location/zipcode entered or within the selected range. Please check your input or adjust your search.