Status:
UNKNOWN
Post-Traumatic Knee Osteoarthritis Following Anterior Cruciate Ligament Reconstruction
Lead Sponsor:
Universitaire Ziekenhuizen KU Leuven
Collaborating Sponsors:
KU Leuven
Conditions:
Anterior Cruciate Ligament Injuries
Post-Traumatic Osteoarthritis of Knee
Eligibility:
All Genders
18-35 years
Brief Summary
The purpose of this trial is to define knee joint pathomechanics (KJPM) in the first 2 years after ACL reconstruction (ACLR) and relate these KJPM with changes in articular cartilage morphology and qu...
Detailed Description
This research project is a longitudinal prospective study. The investigators aim to define the KJPM longitudinally in the first 2 years following ACLR. The investigators relate these KJPM, combined wi...
Eligibility Criteria
Inclusion
- Inclusion Criteria (healthy volunteers):
- Age: 18-35 years
- No previous anterior cruciate ligament (ACL) injury
- Body Mass Index (BMI) between 18-30
- Regular physical activity (active during work or practicing sports regularly)
- Signed informed consent to participate
- Exclusion Criteria (healthy volunteers):
- Major injuries to the lower extremities with absence from sports or daily life activities longer than 2 weeks or that required surgery, less than 6 months before participation
- Pre-existing arthritic disease including inflammatory or infectious arthritis
- Inclusion Criteria (ACL patients):
- Age: 18-35 years
- ACL tear which is recently reconstructed or will be reconstructed after enrollment in the current study (the reconstruction will take place within 6 months after injury) with a Hamstring autograft
- BMI between 18-30
- Regular physical activity (active during work or practicing sports regularly)
- Signed informed consent to participate
- Exclusion Criteria (ACL patients):
- Major injuries to the lower extremities with absence from sports or daily life activities longer than 2 weeks or that required surgery, less than 6 months before participation
- Pre-existing arthritic disease including inflammatory or infectious arthritis
- Image based confirmation of local cartilage lesion grade 4 or major cartilage damage (Kellgren \& Lawrence \> 2)
- Medial collateral ligament damage (\> grade 2)
- Intra-articular knee fractures
- Menisectomy with \<80% remnant
Exclusion
Key Trial Info
Start Date :
November 23 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
April 1 2025
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT06201442
Start Date
November 23 2021
End Date
April 1 2025
Last Update
January 11 2024
Active Locations (1)
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1
Faculty of Kinesiology and Rehabilitation Sciences
Leuven, Vlaams-Brabant, Belgium, 3001