Status:
COMPLETED
The Efficacy of Thyme Honey Mouth Rinse on Polypharmacy-induced Xerostomia
Lead Sponsor:
Ain Shams University
Conditions:
Xerostomia
Eligibility:
All Genders
40-65 years
Phase:
PHASE4
Brief Summary
The study is designed to evaluate the clinical efficacy of thyme honey as a mouth rinse in the management of polypharmacy-induced xerostomia concerning the unstimulated whole salivary flow rate and qu...
Detailed Description
Saliva is a vital component in the mouth and the preservation of humans' general health depends on good oral health. Saliva contains primarily water (99.5%), followed by a 0.3% mixture of inorganic sa...
Eligibility Criteria
Inclusion
- Both genders, aged between 40 and 65 years old.
- Patients using two or more medications known to cause xerostomia or salivary hypofunction (e.g., anxiolytics, anorexiants, anti-asthmatics, anticholinergics, anti-depressants, anti-emetics, anti-histamines, antihypertensives, anti-parkinsonians, anti-psychotics, antithrombotics, muscle relaxants, anticonvulsants, decongestants, diuretics, NSAIDs, or sedatives). Patients taking previous drugs for 240 days or more before the start of the trial and expected to continue.
- Patients are willing to follow all the instructions and attend all the study-associated visits.
Exclusion
- Patients who had received radiation therapy to the head and neck region.
- Patients with other systemic diseases known to cause xerostomia (diabetes mellitus, Sjogren's syndrome, rheumatoid arthritis, systemic lupus erythematosus, hepatitis C virus, tuberculosis, or sarcoidosis).
- Patients using any other medication for their dry mouth condition (pilocarpine, cevimeline) 7 days before entering into the study.
- Patients requiring hospitalization for any medical problem during the study.
- Known hypersensitivity to the active ingredient of the product that will be used as assessed by the medical history questionnaire.
- Vulnerable groups such as pregnant females, prisoners, and mentally or physically handicapped individuals.
Key Trial Info
Start Date :
January 15 2024
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 2 2024
Estimated Enrollment :
32 Patients enrolled
Trial Details
Trial ID
NCT06201923
Start Date
January 15 2024
End Date
December 2 2024
Last Update
April 29 2025
Active Locations (1)
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1
Faculty of dentistry Ain Shams university
Cairo, Egypt