Status:
RECRUITING
Effect of Different Oxygen Concentration on Postoperative Pulmonary Complications After Pulmonary Reexpansion
Lead Sponsor:
RenJi Hospital
Conditions:
Pulmonary Disease
Eligibility:
All Genders
18-79 years
Phase:
NA
Brief Summary
To evaluate the effect of 80% inspiratory oxygen fraction (FiO2) and 30% FiO2 on the incidence of pulmonary complications after pulmonary reexpansion following one-lung ventilation and 2-hour postoper...
Detailed Description
Postoperative pulmonary complications (PPCs) account for the highest proportion (about 84%) among all the factors leading to death in thoracic surgery. High FiO2 was used in perioperative period. Howe...
Eligibility Criteria
Inclusion
- Elective thoracic surgery: lung surgery, esophageal surgery, mediastinal surgery, etc.; 2. One-lung ventilation: double lumen bronchial cannula or occluder is used for isolation of one lung; 3, American Society of Anesthesiology (ASA) grade I \~ III; 4, 18 years ≤ age \< 80 years; 5. Estimated operation time ≥2 hours; 6. Agree to participate and sign the informed consent.
Exclusion
- Severe lung infection occurs within 1 month;
- Coronary heart disease or heart failure occurs within 2 or 3 months;
- Preoperative oxygen saturation is less than 94%; 4, Need continuous oxygen therapy; 5, BMI\>35 kg/m2;
- 6\. Pregnant women; 7. Preoperative Hb\<70g/L or haematocrit\<30%.
Key Trial Info
Start Date :
February 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 30 2026
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT06202586
Start Date
February 1 2024
End Date
April 30 2026
Last Update
January 11 2024
Active Locations (1)
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1
Renji Hospital
Shanghai, Shanghai Municipality, China, 200127