Status:
NOT_YET_RECRUITING
Natriuresis-Guided Diuretic Therapy in Patients With Acute Heart Failure With Reduced Ejection Fraction and Chronic Kidney Disease
Lead Sponsor:
Assiut University
Conditions:
Acute Heart Failure
Chronic Kidney Diseases
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
To investigate the effectiveness and feasibility of natriuresis-guided diuretic therapy as a personalized approach to managing acute heart failure in patients with underlying chronic kidney disease an...
Detailed Description
Natriuresis-guided diuretic therapy represents a promising approach in managing the complex and challenging clinical scenario of patients with acute heart failure (AHF) . These patients present a uniq...
Eligibility Criteria
Inclusion
- Patients presenting with acute heart failure (AHF) with reduced ejection fraction either De novo or ADHF.
- Patients with chronic kidney disease (CKD) stages 1-4.
- Patients aged 18 years or older.
- Patients accept to participate in the study.
Exclusion
- Patients with significant stenotic valvular diseases (MS, AS).
- Patients with acute coronary syndrome.
- Patients with acute cardiogenic shock.
- Patients with dyspnea primarily due to non-cardiac cause (significant COPD).
- Patients with severe renal impairment requiring dialysis (GFR \< 15 mL/min/1.73 m²).
Key Trial Info
Start Date :
January 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 1 2025
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT06203236
Start Date
January 1 2024
End Date
November 1 2025
Last Update
January 12 2024
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