Status:
TERMINATED
Evaluation of Infigratinib in Patients With Locally Advanced or Metastatic Gastric Cancer or GEJ Adenocarcinoma
Lead Sponsor:
LianBio LLC
Conditions:
Gastric Cancer
Gastroesophageal Junction Adenocarcinoma
Eligibility:
All Genders
18-99 years
Phase:
PHASE2
Brief Summary
This is a multicenter, open-label, single arm phase II study to evaluate the efficacy and safety of Infigratinib in patients with locally advanced or metastatic GC or GEJ patient with FGFR2 gene ampli...
Eligibility Criteria
Inclusion
- 18 years and older
- Histologically or cytologically confirmed locally advanced or metastatic gastric adenocarcinoma, or gastroesophageal junction adenocarcinoma.
- Failed at least 2 lines of prior systemic therapy
- Willing to undergo tumor biopsy or provide FFPE samples for central lab testing.
- At least one measurable tumor lesion by RECIST v1.1
- Eastern cooperative oncology group (ECOG) performance status of 0 or 1.
- Life expectancy ≥3 months.
- Willing to participate in this study and sign informed consent form, able to read and understand the study, follow the procedures.
Exclusion
- History of other primary malignancies within 3 years except adequately treated in situ carcinoma of the cervix or non-melanoma carcinoma of the skin or any other curatively treated malignancy that is not expected to require treatment for recurrence during the study.
- Previous or current treatment of a mitogen-activated protein kinase (MAPK-MEK) or selective FGFR inhibitor.
- Any known hypersensitivity to infigratinib or its excipients.
- History and/or current evidence of extensive tissue calcification.
- Current evidence of endocrine alterations of calcium/phosphate homeostasis.
- Have impairment of gastrointestinal (GI) function or GI disease that may significantly alter the absorption of oral infigratinib (such as, ulcerative diseases, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome, small bowel resection).14. Laboratory abnormality as defined in protocol.
- Considered unsuitable to participate in the study by Investigator
Key Trial Info
Start Date :
October 19 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 31 2024
Estimated Enrollment :
6 Patients enrolled
Trial Details
Trial ID
NCT06206278
Start Date
October 19 2023
End Date
May 31 2024
Last Update
August 14 2024
Active Locations (30)
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1
Anhui Provincial Cancer Hospital
Hefei, Anhui, China, 230031
2
The Second Hospital of Anhui Medical University
Hefei, Anhui, China, 230601
3
Beijing Cancer Center
Beijing, Beijing Municipality, China, 100142
4
The First Affiliated Hospital of Xiamen University
Xiamen, Fujian, China