Status:
RECRUITING
The Gut Microbiome and Serum Metabolites As a Biological Mechanism Underlying Pain in Kidney Transplantation
Lead Sponsor:
University of Illinois at Chicago
Conditions:
Kidney Transplant Symptoms
Gut Microbiome
Eligibility:
All Genders
18+ years
Brief Summary
Study Summary Nearly half (47%) of people with end-stage kidney disease (ESKD) whose kidney function is restored after kidney transplantation experience chronic pain compared to 19% of adults in the U...
Detailed Description
Objectives Aim 1: To determine differential dynamic temporal relationships between microbial composition/ functional genes and circulating serum metabolites in KTRs with pain vs no pain. H1: Specific ...
Eligibility Criteria
Inclusion
- Receiving a kidney transplant at the University of Illinois Hospital \& Health Sciences System (UI Health) Transplant Center at the University of Illinois Chicago (UIC),
- 18 years of age or older (adult), and
- Understand the study process and provide written informed consent to participate.
Exclusion
- Having taken systemic antimicrobials (except prophylactic penicillin) in the preceding 4 weeks.
- Having received a previous solid organ transplant.
- History of colon cancer or of an inflammatory bowel disease.
- Planning to receive a multiorgan transplant (e.g., simultaneous pancreas and kidney transplant).
- Having a history of Clostridium difficile infection in the preceding 8 weeks.
Key Trial Info
Start Date :
October 9 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
March 1 2028
Estimated Enrollment :
133 Patients enrolled
Trial Details
Trial ID
NCT06206486
Start Date
October 9 2023
End Date
March 1 2028
Last Update
February 27 2025
Active Locations (1)
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1
UI Health
Chicago, Illinois, United States, 60612