Status:
COMPLETED
Clinical Characteristics and Treatment of Anosmia and Ageusia Due to SARS-CoV2 Variants
Lead Sponsor:
Sherifa Ahmed Hamed
Conditions:
Post-covid-19 Persistent Smell and Taste Disorders
Eligibility:
All Genders
10-70 years
Phase:
PHASE4
Brief Summary
The SARS-CoV-2 pandemic has consisted of multiple surges of infection because of continuous viral mutations. The WHO and CDC have defined the main SARS-CoV-2 variants based on international and nation...
Detailed Description
The diminished senses of smell (or hyposmia/anosmia) and taste (or hypogeusia/ageusia) have been commonly reported after infection by ancestral Wuhan, alpha and delta strains of the SARS-CoV-2 virus i...
Eligibility Criteria
Inclusion
- Children and adults with sudden hyposmia/anosmia and/or hypoageusia/ageusia during COVID-19 pandemics (2020-2024).
- Persisting symptoms were defined as disorders lasting ≥6 months.
- Cooperation during objective evaluation
- compliance to drug treatment or olfactory and gustatory trainings for at least 8 weeks.
Exclusion
- Prior neurological, medical or psychiatric disease which are known as a cause of progressive olfactory or gustatory dysfunction
- Nasal congestion
- Nasal polyps
- Surgery or head trauma or radiation for head and neck cancers as may result in injury to the nerves that control smell
- Exposure to toxic chemicals (such as pesticides and solvents) Cocaine or other drug abuse
- Lack of compliance to drug treatment or olfactory and gustatory trainings for at least 8 weeks.
- Lack of cooperation to complete the objective testings.
Key Trial Info
Start Date :
August 30 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 30 2024
Estimated Enrollment :
160 Patients enrolled
Trial Details
Trial ID
NCT06208540
Start Date
August 30 2021
End Date
May 30 2024
Last Update
August 5 2024
Active Locations (2)
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1
Assiut University Hospitals, Faculty of Medicine, Hospital of Neurology, Neurosurgery and Psychiatry, Assiut University Hospital, Assiut, Egypt
Asyut, Egypt, 71516
2
Assiut University, Faculty of Medicine, Hospital of Neurology, Psychiatry and Neurosurgery
Asyut, Egypt, 71516