Status:
COMPLETED
Is it Necessary for Patients With a Positive Urine Culture to Achieve a Negative Result After Antimicrobial Treatment Before Undergoing Percutaneous Nephrolithotomy?
Lead Sponsor:
Junhao Zheng
Conditions:
Kidney Calculi
Urinary Tract Infections
Eligibility:
All Genders
18-80 years
Brief Summary
Objective: The current European Association of Urology (EAU) guidelines do not provide clear recommendations on whether patients with a positive urine culture(UC) should wait until the culture turns n...
Detailed Description
For large renal stones, percutaneous nephrolithotomy (PCNL) is the recommended standard surgical approach, especially in cases involving infectious renal stones. Postoperative infections have become t...
Eligibility Criteria
Inclusion
- Age ≥ 18 years.
- Renal stone diameter ≥ 2 cm, complex renal stones, or failed ESWL treatment.
- Consent to undergo PCNL with a positive midstream urine culture preoperatively.
- ASA score of I or II.
Exclusion
- Coexisting renal tumor.
- Use of antibiotics within the past two weeks.
- Renal dysfunction (serum creatinine \>451 μmol/L).
- Unresolved hemorrhage or coagulation abnormalities.
- Patients who have undergone percutaneous renal fistula or have a ureteral stent in place on the affected side.
- Simultaneous bilateral renal stone surgery.
- Severe underlying diseases, such as respiratory or circulatory insufficiency, that cannot tolerate anesthesia or surgery.
- Pregnant or lactating women.
Key Trial Info
Start Date :
March 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 10 2024
Estimated Enrollment :
147 Patients enrolled
Trial Details
Trial ID
NCT06210425
Start Date
March 1 2021
End Date
November 10 2024
Last Update
November 21 2025
Active Locations (1)
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1
The First Affiliated Hospital of Guangzhou Medical University
Guangzhou, GuangGong, China, 510500