Status:
RECRUITING
Prospective Registry of Endovascular Thrombectomy for eXtra-Large Ischemic Stroke
Lead Sponsor:
Zhongming Qiu
Collaborating Sponsors:
Xiangtan Central Hospital (The Affiliated Hospital of Hunan University)
Conditions:
Acute Ischemic Stroke (AIS)
Acute Ischemic Stroke From Large Vessel Occlusion
Eligibility:
All Genders
18+ years
Brief Summary
Since 2015, many randomized trials have shown that endovascular thrombectomy improve functional outcomes in acute ischemic stroke patients with large vessel occlusion. Recently, five randomized contro...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Clinical inclusion criteria
- Age ≥18 years;
- Presenting with acute ischemic stroke within 24 hours of time from last known well;
- The patient or patient's representative signs a written informed consent form before enrollment.
- Neuroimaging inclusion criteria
- Occlusion of internal carotid artery, or the middle cerebral artery M1 or M2 segments confirmed by computed tomography angiography, magnetic resonance angiography, or digital subtraction angiography;
- The baseline ASPECTS is 0 to 2 based on NCCT or diffusion weighted imaging, or cerebral extra-large ischemic core volume ≥85ml (defined as relative cerebral blood flow \<30% on CT perfusion or an apparent diffusion coefficient \<620×10\^-6 mm2/s on MRI).
- Exclusion criteria
- CT or MRI evidence of acute intracranial hemorrhage;
- Evidence of mass effect with ventricular effacement, midline shift or herniation on baseline imaging;
- Females who are pregnant, or those of childbearing, potential with positive urine or serum beta Human Chorionic Gonadotropin test;
- Previous bleeding disorders, severe heart, liver or kidney disease, or sepsis;
- Any terminal illness with life expectancy less than 6 months;
- Participation in other clinical treatment trials.
Exclusion
Key Trial Info
Start Date :
January 20 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
March 31 2026
Estimated Enrollment :
1000 Patients enrolled
Trial Details
Trial ID
NCT06210633
Start Date
January 20 2024
End Date
March 31 2026
Last Update
December 31 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Xiangtan Central Hospital
Xiangtan, Hunan, China, 421001