Status:
UNKNOWN
Transcranial Alternating Current Stimulation (tACS) on Serotonin-1A Receptor in Depression
Lead Sponsor:
Xuanwu Hospital, Beijing
Conditions:
Major Depressive Disorder
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
This study will apply a comprehensive tools that integrates neuroimaging, psychological evaluation, and sleep monitoring through 18F-MPPF PET/MR, neuropsychological tests, and polysomnography (PSG) to...
Detailed Description
5-HT1A receptor appears to be significantly involved in the effectiveness of electroconvulsive therapy (ECT). Like alternating current in ECT, tACS also applies alternating current to intervene in neu...
Eligibility Criteria
Inclusion
- Inclusive Criteria:
- 18 to 65 years old, Chinese, male or female.
- Non-psychotic major depressive disorder according to DSM-IV.
- HAMD-17 total score ≥ 17 at the baseline.
- Currently experiencing an acute episode.
- No history of prior treatment with psychotropic medications.
- Understanding of all aspects of the research protocol and the ability to provide informed consent.
- Exclusion Criteria for patients:
- Unable to do PET/MR examinations.
- Have secondary insomnia disorders, anxiety disorders, or depressive disorders caused by physical illnesses.
- Severe or unstable organic diseases.
- Pregnant or lactating women or those planning a pregnancy in the near future.
- Alcohol or substance dependence or abuse within the past year.
- Received electroconvulsive therapy or transcranial magnetic stimulation in the month preceding enrollment.
- Skin damage at the electrode placement site or those allergic to electrode gel or adhesives.
- Participated in any other clinical trials within the month before baseline.
- Any inappropriate conditions considered by the study group.
- Inclusion Criteria for healthy volunteers
- To undergo PET/MR examinations.
- Be matched with the patient group regarding age, sex, and educational level.
- Exclusion Criteria for healthy volunteers:
- Those who are enrolled in other clinical studies.
- The inappropriate conditions considered by the study group.
Exclusion
Key Trial Info
Start Date :
January 31 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 31 2025
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT06211140
Start Date
January 31 2024
End Date
May 31 2025
Last Update
January 31 2024
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Xuanwu Hospital
Beijing, Beijing Municipality, China, 100053