Status:
RECRUITING
Effects on Biotrauma of NMBAs and PP Association During ARDS
Lead Sponsor:
Assistance Publique Hopitaux De Marseille
Conditions:
Moderate to Severe Acute Respiratory Distress Syndrome
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The improved survival of patients with acute respiratory distress syndrome (ARDS) over the last decades is related to the use of so-called "protective" mechanical ventilation. Two therapies have been ...
Eligibility Criteria
Inclusion
- Age \> 18 years
- Written informed consent of proxy to the study participation
- Invasive mechanical ventilation for ≤ 72 hours at inclusion
- Criteria of moderate to severe ARDS according to the Berlin definition
- Patients covered by or having the rights to social security
Exclusion
- Pregnant or breast-feeding women, patients deprived of freedom or under legal authority
- Patients having undergone previous PP sessions during the same stay
- Patients who had already been curarized prior to inclusion
- Patient currently receiving ECMO or any technique of extracorporeal CO2 removal at the time of inclusion
- Patient with a contraindication to PP
- Previous hypersensitivity or anaphylactic reaction to any NMBA
- Chronic respiratory insufficiency with oxygen or long-term ventilation
- SAPS II score at the time of enrollment \> 75
- Patients who are moribund or for whom limitations of active therapies have been decided.
Key Trial Info
Start Date :
August 8 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT06212492
Start Date
August 8 2024
End Date
December 1 2026
Last Update
August 20 2024
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Service Médecine Intensive et Réanimation
Marseille, France, 13015