Status:
RECRUITING
Beneficial Effect of Silymarin in Ulcerative Colitis
Lead Sponsor:
Tanta University
Conditions:
Ulcerative Colitis
Eligibility:
All Genders
18-65 years
Phase:
PHASE2
Brief Summary
The goal of this clinical trial is to evaluate the possible beneficial effect of silymarin in Ulcerative Colitis adult patients receiving mesalamine. This is trial that will be conducted on 44 adult p...
Detailed Description
Inflammatory Bowel Disease (IBD), is a debilitating progressive chronic inflammatory disorder of the small intestine and colon characterized by alternative phases of clinical relapse and remission. IB...
Eligibility Criteria
Inclusion
- Adults of both sexes aged from 18 years to 65 years.
- Adults with normal kidney and liver functions.
- Patients who sign the consent and willing to participate in the study.
- Patients with UC according to American College of Gastroenterology Clinical Guidelines for diagnosis Ulcerative Colitis having clinical signs and symptoms with a completed medical workup, colonoscopy, pathological and laboratory data confirming UC
Exclusion
- Previous hypersensitivity or anaphylactic reaction to silymarin.
- Significant renal and hepatic impairment.
- Patients who refuse to participate.
- Pregnant women, breastfeeding women and smokers.
- Patients taking corticosteroids or biological therapy.
- Patients taking any other antioxidants.
- Patients having other concomitant diseases where oxidative stress is involved in the etiology such as chronic liver disease, pulmonary infection.
Key Trial Info
Start Date :
February 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2025
Estimated Enrollment :
44 Patients enrolled
Trial Details
Trial ID
NCT06213857
Start Date
February 1 2025
End Date
June 1 2025
Last Update
March 5 2025
Active Locations (2)
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1
Mabarra Hospital
Asyut, Egypt, 71511
2
Rajhy Hospital
Asyut, Egypt, 71511