Status:
RECRUITING
Modulating Temporoparietal Junction Mentalizing-Related Activity in Autism Spectrum Disorder (ASD) Using Transcranial Magnetic Stimulation (TMS)
Lead Sponsor:
Yale University
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
Autism Spectrum Disorder
Eligibility:
All Genders
18-35 years
Phase:
NA
Brief Summary
The goal of this observational study is to test the modulation effect of different transcranial magnetic stimulation (TMS) on the neural network supporting our ability to create mental representations...
Detailed Description
All participants will be scheduled for four study sessions that include a baseline and three subsequent sessions that will each include two functional magnetic resonance imaging (fMRI) scans, one pre ...
Eligibility Criteria
Inclusion
- Estimated full-scale IQ\>80
- Right handed
- Fluent in English
- Individual can cooperate with all study's procedures
- No history of neurological disorder (e.g. epilepsy) or neurosurgery
- No major medical condition (e.g. cancer, heart failure)
- No history of significant head injury
- No primary relatives with history of any neurological disorder with a potentially hereditary basis, including epilepsy or MS
- No current use of medications with psychotropic (e.g., benzodiazepines) or anti- or pro-convulsants
- No current substance use (determined by urine screen and breathalyzer in all visits)
- Negative urine pregnancy (women) test at time of MRI scans
- No MR contra-indications (e.g. in-body metal implant, severe claustrophobia)
- No previous participation in our lab in a study including the Domino fMRI task
- For ASD: Stable medication treatment 4 weeks prior to study enrollment
- For Control Group: No current or history of psychiatric disorders, other than simple phobia, and/or primary relatives with ASD
Exclusion
- \-
Key Trial Info
Start Date :
April 3 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2027
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT06214065
Start Date
April 3 2024
End Date
October 1 2027
Last Update
April 24 2025
Active Locations (1)
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1
Olin Neuropsychiatry Research Center (ONRC)
Hartford, Connecticut, United States, 06106