Status:
COMPLETED
Intrarenal Venous Flow Change During Fluid Removal in Critically Ill Patients: A Prospective Exploratory Study
Lead Sponsor:
Mahidol University
Conditions:
Critical Illness
Fluid Overload
Eligibility:
All Genders
18+ years
Brief Summary
This clinical trial aims to study intrarenal venous flow patterns change, VExUS score change, and LUS score change during fluid removal treatment in critically ill patients
Detailed Description
Background: In patients with heart failure, intrarenal venous flow patterns could change depending on the level of congestion and was strongly correlated with death from cardiovascular disease and unp...
Eligibility Criteria
Inclusion
- Adult patients aged 18 years old or older who will be admitted to the medical intensive care unit
- Expected to be hospitalized in the intensive care unit for more than 120 hours.
- The patient has stable vital signs without the need for vasoactive medications or rapid fluid resuscitation (at least 500 milliliters of colloid or 1000 milliliters of crystalloid via rapid intravenous infusion) for a minimum consecutive period of 12 hours. This includes cases where the patient receives norepinephrine at a rate not exceeding 0.1 micrograms per kilogram per minute and dobutamine at a rate not exceeding 10 micrograms per kilogram per minute, or when the patient can maintain a continuous reduction in vasoactive medications for a minimum consecutive period of 12 hours.
- The patient does not exhibit signs suggestive of inadequate organ perfusion, such as mottling skin, a capillary refill time of more than 2 seconds when nailbeds are pressed and released, or cold extremities.
- The patients require fluid removal through decisions made by attending staff or clinical guidelines, which may involve the administration of diuretics or Renal Replacement Therapy.
Exclusion
- Underlying chronic kidney disease (eGFR\< 30) before enrollment
- Chronic renal replacement therapy (RRT) before enrollment such as on intermittent hemodialysis, peritoneal dialysis
- Decompensated cirrhosis with portal hypertension
- Inferior vena cava, portal vein, hepatic, renal vein thrombosis
- Ureteral obstruction
- Intraabdominal hypertension (Intraabdominal pressure \> 12 mmHg)
- Previous allergic or anaphylactic to diuretic
- Pregnant women
- Transplanted kidney, transplanted liver
- Patients with do-not-resuscitate (DNR) orders or decisions to withhold life-sustaining treatments
- Patients or their legally authorized representatives (LAR), who decline participation in the study or are unable to provide informed consent before enrollment
Key Trial Info
Start Date :
January 23 2024
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 13 2024
Estimated Enrollment :
52 Patients enrolled
Trial Details
Trial ID
NCT06216119
Start Date
January 23 2024
End Date
October 13 2024
Last Update
May 29 2025
Active Locations (1)
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1
Siriraj Hospital, Mahidol University
Bangkok Noi, Bangkok, Thailand, 10700