Status:
RECRUITING
OPT-CAD Score GUIded Dual ANtiplatelet De-esCalation Time
Lead Sponsor:
Shenyang Northern Hospital
Conditions:
Acute Coronary Syndrome
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
Monotherapy with a P2Y12 inhibitor after a minimum period of DAPT following percutaneous coronary intervention (PCI) is an emerging de-escalation antiplatelet strategy in recent years. However, the op...
Detailed Description
Antiplatelet therapy is a cornerstone of secondary prevention in patients with coronary artery disease. However, as the use of more potent antithrombotic therapy, it not only lowers ischemic risk but ...
Eligibility Criteria
Inclusion
- Adult patients with ages of 18-80 years;
- Patients with clinically diagnosed ACS who have undergone at least one DES implantation;
- Individuals capable of completing the OPT-CAD scoring calculation;
- Researchers assessing that participants can tolerate at least a 12-month duration of DAPT therapy;
- Written informed consent provided.
Exclusion
- Left main coronary artery lesion PCI;
- Allergy to study drugs such as aspirin, clopidogrel, or ticagrelor;
- Meeting 1 major or 2 minor criteria for high bleeding risk according to the ARC-HBR criteria;
- Anticipated need for revascularization or surgical intervention within 12 months;
- Severe ischemia or hemorrhage events during the current hospitalization;
- Life expectancy of other serious diseases is less than 1 year;
- Pregnant or women of childbearing age who intend to conceive within 1 year;
- Participation in other clinical trials while still under observation;
- Researchers considering ineligibility for enrollment.
Key Trial Info
Start Date :
July 2 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2027
Estimated Enrollment :
3490 Patients enrolled
Trial Details
Trial ID
NCT06216821
Start Date
July 2 2024
End Date
December 31 2027
Last Update
September 10 2025
Active Locations (1)
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1
General Hospital of Northern Theater Command
Shenyang, Liaoning, China, 110016