Status:
RECRUITING
BCAAs, Muscle Protein Synthesis and Glucose Uptake
Lead Sponsor:
Wageningen University
Conditions:
Healthy
Eligibility:
All Genders
18-35 years
Phase:
NA
Brief Summary
The present study aims to quantify the insulin sensitivity and the skeletal muscle protein synthetic response to consuming a test drink containing all amino acids or all amino acids except for BCAAs.
Detailed Description
Twenty-eight healthy, young volunteers will receive a stable isotope tracer infusion (7.5h) combined with repeated blood and muscle sampling, to measure muscle protein synthesis rate in the postabsorp...
Eligibility Criteria
Inclusion
- Aged from 18-35 years
- 5 \< Body mass index \< 30 kg·m2
- Recreationally active (performing non-competitive physical exercise at least one time per week for minimally 30 minutes)
Exclusion
- Smoking
- Diabetes (Type 1, Type 2, or genetic form of diabetes)
- Any diagnosed cardiovascular (heart) disease or high blood pressure (≥140 mmHg systolic and/or ≥90 mmHg diastolic)
- Chronic use of any prescribed or over the counter pharmaceuticals (excluding oral contraceptives and contraceptive devices)
- Known allergy to lidocaine
- Regular use of dietary protein and/or amino acid supplements (\>3 times per week)
- Currently involved in a structured progressive resistance training programme (\>3 times per week)
- A personal or family history of thrombosis (clots), epilepsy, seizures, or schizophrenia.
- Any previous motor disorders or disorders in muscle and/or lipid metabolism
- Presence of an ulcer in the stomach or gut and/or strong history of indigestion
- Known severe kidney problems
- Pregnant or breastfeeding
- Unable to give consent
Key Trial Info
Start Date :
January 10 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
28 Patients enrolled
Trial Details
Trial ID
NCT06218264
Start Date
January 10 2024
End Date
December 31 2025
Last Update
May 29 2025
Active Locations (1)
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1
Wageningen University and Research
Wageningen, Gelderland, Netherlands, 6708 WD